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CP 316311
CAS No. 175139-41-0
CP 316311( —— )
Catalog No. M33325 CAS No. 175139-41-0
CP 316311 is a specific CRF1 receptor antagonist with potential antidepressant activity and may be used in the study of depression.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 445 | Get Quote |
|
| 5MG | 506 | Get Quote |
|
| 10MG | 649 | Get Quote |
|
| 25MG | 854 | Get Quote |
|
| 50MG | 1159 | Get Quote |
|
| 100MG | 1512 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCP 316311
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NoteResearch use only, not for human use.
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Brief DescriptionCP 316311 is a specific CRF1 receptor antagonist with potential antidepressant activity and may be used in the study of depression.
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DescriptionCP 316311 is a potent and selective CRF1 receptor antagonist with an IC50 value of 6.8 nM.
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In VitroCP 316311 fully antagonizes CRF-stimulated adenylate cyclase activity in rat cortex and at human CRF1 receptors endogenously expressed in IMR32 cells with apparent Ki values of 7.6 and 8.5 nM, respectively.
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In VivoCP 316311 (3.2 mg/kg) inhibits 125I-oCRF binding by >80% in rats. CP 316311 significantly attenuates activation of the hypothalamic?pituitary?adrenal (HPA) axis, with an MED value of 10 mg/kg, p.o. CP 316311 blocks the effects of both the exogenous and endogenous CRF in the CNS. CP 316311 blocks the effects induced by the exogeneous or endogeneous CRF in the brain in rat models.
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Synonyms——
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PathwayGPCR/G Protein
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TargetCRF Receptor
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RecptorCRFR
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Research Area——
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Indication——
Chemical Information
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CAS Number175139-41-0
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Formula Weight327.46
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Molecular FormulaC21H29NO2
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Purity>98% (HPLC)
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Solubility——
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SMILESN=1C(OC=2C(=CC(=CC2C)C)C)=C(C(OC(CC)CC)=CC1C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chen YL, et al. Synthesis and SAR of 2-aryloxy-4-alkoxy-pyridines as potent orally active corticotropin-releasing factor 1 receptor antagonists. J Med Chem. 2008 Mar 13;51(5):1377-84.?
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